Immunohistochemical Ex-pression
of p16 in Carcinoma Ex-pleomorphic
Adenoma (undifferentiated and
Adenocarcinoma Types)
Published: December 1, 2013 | DOI: https://doi.org/10.7860/JCDR/2013/.3851
Bassel Tarakji, Mohammed Alsakran Altamimi, Kusai Baroudi, ,Mohammad .Z. Nassain, Faris Q Alenzi
1. Faculty, Head of Department of Oral Maxillofacial Sciences, Alfarabi College of Dentistry and Nursing, Kingdom of Saudi Arabia, Riyadh.
2. Faculty, Department of Restorative Dental Sciences, Alfarabi College of Dentistry and Nursing, Kingdom of Saudi Arabia, Riyadh.
3. Faculty, Department of Restorative Dental Sciences, Alfarabi College of Dentistry and Nursing, Kingdom of Saudi Arabia, Riyadh.
4. Faculty, Department of Restorative Dental Sciences, Alfarabi College of Dentistry and Nursing, Kingdom of Saudi Arabia, Riyadh.
5. Faculty, College of Applied Medical Sciences, Prince Salman University, Al-Kharj, Saudi Arabia.
Correspondence
Dr Bassel Tarakji,
Faculty, Head of Department of Oral Maxillofacial Sciences, Alfarabi College of Dentistry and Nursing,
Kingdom of Saudi Arabia, Riyadh
E-mail: denpol@yahoo.co.uk
Objective: This study was aimed at characterizing alterations in the immunohistochemical expression of p16 in carcinoma ex-pleomorphic adenomas. Study Design: A selected series of 27 cases of carcinoma ex-pleomorphic adenomas were examined.
Results: The results showed that p16 expression in non tumour duct cells was strongly positive nuclear staining in 23 (85%) cases out of 27 cases, that 3 (11.1%) had moderate staining, and that 1 (3.7%) had weak staining. p16 expression in carcinoma ex-pleomorphic adenomas was indicated as a negative nuclear staining in 22 (81.4%) cases out of 27cases, and 5 (18.5%) cases expressed moderate staining.
Conclusion: This study suggests that alteration of p16 expression is detected in carcinoma ex-pleomorphic adenomas. p16 has a role in development of carcinoma ex-pleomorphic adenomas.
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